Over 40 years of reliable U.S. supply

Grace’s FCMS has been developing and manufacturing high-value custom APIs for over 40 years, and is renowned as one of the market’s consistent, long-standing suppliers across the pharmaceutical and nutraceutical industries. With facilities in South Haven, Michigan, Albany, Oregon and Tyrone, Pennsylvania, all our API development and manufacturing is done domestically in the U.S., mitigating supply chain risk and optimizing timelines for customers.

Grace's FCMS has experienced staff

Experienced Staff

Our personnel across our three U.S. sites have notable long tenures with Grace's FCMS, contributing to the consistency, continuity and experience that bring value to customers. Many of our key team members have been with Grace's FCMS for 15–30 years, which delivers a tremendous depth of know-how and experience with specific processes.

Four decades of manufacturing

South Haven is our cGMP facility with over 40 years of API experience and an excellent compliance record. Grace's FCMS also has a renowned portfolio of generic APIs that were developed during this long legacy and are reliably supplied to companies around the world, highlighting the drug substance expertise at Grace's FCMS.

Available Technologies & Chemistries

Technology Solutions

  • Lithiations
  • Cryogenic processing
  • Liquid ammonia reactions
  • Zirconium reactor / hot caustic
  • Specialty polymerizations
  • Halogenations
  • Ultra-low vacuum distillation
  • Pyrophorics
  • Moisture-sensitive reactions
  • Corrosive & high-temperature distillation


  • Acid chlorides
  • Alkylation
  • Amide formation
  • Bromination
  • Chlorination
  • Condensation
  • Cryogenic reactions
  • Decarboxylation
  • Dehydration
  • Dehydrofluorination
  • Epoxidation
  • Esterification
  • Ether formation
  • Freidel-crafts
  • Grignard
  • Hydrazone formation
  • Hydrogenation
  • Hydrolysis
  • Imine formation
  • Lithiation
  • Nitration
  • Oxidation with peroxide
  • Phosphonation
  • Polymerizations
  • Rearrangements
  • Reduction
  • Sulfonation

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Start a new project

Grace FCMS is highly motivated to talk about API, intermediates or RSM projects that you are looking to outsource to a reliable supplier. Click below to submit a contact form.

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Related Capabilities

View the other pages in this section to gain an understanding of the fully integrated drug substance capabilities offered by Grace FCMS.

Generic APIs

Grace FCMS has developed some of the industry’s best-known APIs, which are available to developers as our portfolio of quality U.S.-sourced generic products.

Learn more